Fungal β-glucans and their receptors

Abstract

β-Glucans are predominant carbohydrates found in the cell wall of many fungi which possess immune-modulating activities. Recognition of these carbohydrates is thought to occur via multiple receptors and at least four different receptors have been identified, including Dectin-1, complement receptor 3, lactosylceramide, and scavenger receptors. There is growing evidence that β-glucan recognition is an important component of anti-fungal immunity, but may also contribute to development of certain diseases. In this chapter we will review each of these aspects, highlighting the roles of β-glucans and their receptors in fungal recognition and immunity