Oral hypoglycemic effect of Caesalpinia bonducella

Abstract

The blood sugar lowering efficacy of the aqueous extract of Caesalpinia bonducella F. (seed shell) was evaluated in fasted, fed, glucose loaded, streptozotocin diabetic, and alloxan diabetic rat models. The extract was administered orally at a dose of 250 mg/kg of rat body weight. It produced very significant blood sugar lowering (at least P < 0.005) in glucose loaded, streptozotocin diabetic, and alloxan diabetic models. However, effects were not so pronounced in fasted and fed models. As a whole, Caesalpinia bonducella can be regarded as a good oral hypoglycemic agent in rat. © Swets & Zeitlinger.