The strobilurins - new antifungal antibiotics from the basidiomycete strobilurus tenacellus

Abstract

The strobilurins are two antifungal antibiotics which were isolated from the mycelium of Slrobilurus tenacellus strain No. 21602. The strobilurins A and B are highly active against yeasts and filamentous fungi. In vitro antitumor activity was tested using cells of the ascitic form of Ehrlich carcinoma. The strobilurins strongly inhibited the incorporation of radioactive leucine, uridine, and thymidine into the acid-insoluble fraction of cells (protein, RNA, and DNA). The molecular formulas as determined by high resolution mass spectrometry are CieHisOa for strobilurin A and CnHi9C104 for strobilurin B. © 1977, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.