Structural stability and length of I-motif of G-quartet in DNA octaplex.

Abstract

To confirm that longer DNA strands with sequences gcGA[G](n)Agc can form an octaplex, X-ray analyses at n>1 have been performed. Several crystals of d(gcGA[G]2Agc) are obtained under different conditions. It has been found that the crystal obtained with cobalt hexamine suggests a hexaplex formation, while the crystal obtained with Mg2+ and Na+ ions suggests an octaplex formation.