Deciphering the genetic blueprint of cerebellar development by the gene expression profiling informatics

Abstract

The brain is the ultimate genetic system to which a large number of genes are devoted. To extract and visualize biological information from such large data sets accumulated in the post-sequencing era, the use of bioinformatics would be a very powerful means. To understand the genetic basis of mouse cerebellar postnatal development, we have analyzed the whole transcription or gene expression (transcriptome) during the developmental stages on a genomewide basis, and have systematized the spatio-temporal gene expression profile information in-a comprehensive database (Cerebellar Development Transcriptome [CDT] database) from a bioinformatics point of view. This CDT database would open up a new field for deciphering the genetic blueprint for cerebellar development. © Springer-Verlag Berlin Heidelberg 2004.