A novel method for the synthesis of nonsymmetrical 3,3’-(aryl/alkyl-methylene)bis-2-hydroxy-1,4-naphthoquinones was developed by using the Mannich adduct of naphthoquinone and the reaction with another moiety of 2-hydroxy-1,4-naphthoquinone. This novel method produces for the first time nonsymmetrical 3,3’-(aryl/alkyl-methylene)bis-2-hydroxy-1,4-naphthoquinones. In a preliminary study, these compounds (15c, 15f and 15h) were evaluated regarding their effect over the viability of PC3 metastatic prostate cancer cell using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays at 100 μM. Three of these compounds presented relevant cytotoxic effects at 72 h posttreatment.
CITATION STYLE
Ribeiro, R. C. B., de Freitas, P. P., Moreira, C. S., de Moraes, L. G. C., Moraes, M. G., da Silva, F. C., … Ferreira, V. F. (2020). A new strategy for the synthesis of nonsymmetrical 3,3’-(aryl/alkyl-methylene) bis-2-hydroxy-1,4-naphthoquinones and their cytotoxic effects in PC3 prostate cancer cells. Journal of the Brazilian Chemical Society, 31(2), 288–297. https://doi.org/10.21577/0103-5053.20190172
Mendeley helps you to discover research relevant for your work.