Therapeutic Evaluation of Ethanolic Bee Pollen Extract from Malaysian Stingless Bee in MCF-7 and MCF-10A Cell Lines

3Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

Bee pollen is a complete food containing comprehensive nutrients and therapeutic properties that could eliminate free radicals. Three stingless bee species native to Malaysia were used to prepare bee pollen ethanolic extracts (BPE): Geniotrigona thoracica, Heterotrigona itama, and Tetrigona apicalis. The methodology used in this study was a trypan blue exclusion assay for cell proliferation activity in cultured breast adenocarcinoma human cell lines (MCF-7) and mammary epithelial human cell lines (MCF-10A). In addition, the therapeutic index (TI) was analyzed to assess the relative antiproliferative activity of BPE on cancer versus normal cells. Geniotrigona thoracica BPE exhibited the highest therapeutic index (TI = 3.12) compared to H. itama (TI = 1.16) and T. apicalis (TI = 0.90) BPE. Each species represents different bioactive compounds due to different pollen foraging activities. Therefore, the highest TI species (G. thoracica) could be a potential candidate to be developed as a potential chemotherapeutic agent.

Cite

CITATION STYLE

APA

Fadzilah, N. H., & Omar, W. A. W. (2023). Therapeutic Evaluation of Ethanolic Bee Pollen Extract from Malaysian Stingless Bee in MCF-7 and MCF-10A Cell Lines. Pertanika Journal of Tropical Agricultural Science, 46(1). https://doi.org/10.47836/PJTAS.46.1.03

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free