Observational study of SARS-CoV-2 antibody immune response in a cohort of patients at a North Suburban Chicago, Illinois, in a physician’s practice

  • Osher G
  • Lamb C
  • Ibarra Y
  • et al.
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Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The application of point of care serological testing can help determine past infection and assist healthcare workers assess patient risk. Method: An observational study of 114 subjects in North Suburban Chicago, Illinois, was performed using the Clungene ® lateral flow immunoassay (LFI). Patients’ PCR test results and clinical symptoms were used to compare the seroconversion rate of this patient population with the surrounding community. Results: Excluding 1 aberrant result, there was 100% positive agreement (10) between PCR and antibody (IgG or IgM) test results. There were 7 patients who did not have a prior PCR test who were positive for IgG; 5 of the 7 had clinical symptoms consistent with possible exposure and 2 were asymptomatic. There was 1 person with a suspected exposure to an infected person who was IgM positive. Ninety-five asymptomatic patients were seronegative. The overall rate of 15.9% seroconversion (IgG or IgM) is consistent with other community-based testing results in the North Suburban Chicago, Illinois area.Conclusion: Rapid screening tests to identify antibody positive patients recovered from coronavirus disease-2019 can be a useful tool for healthcare professionals to determine or confirm past infection.Statement of novelty: Limited data is available on the use of point of care serological testing to assist healthcare professionals with the assessment of their patient population regarding past SARS-CoV-2 infectivity and seroconversion. The present study successfully investigated the use of a point of care antibody test in a physician’s office to determine which patients have developed antibodies, indicating an immune response to SARS-CoV-2, and to assist with decisions on whether patients should pursue normal social and workplace activities.

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APA

Osher, G., Lamb, C. C., Ibarra, Y., & Erickson-Samson, D. (2020). Observational study of SARS-CoV-2 antibody immune response in a cohort of patients at a North Suburban Chicago, Illinois, in a physician’s practice. LymphoSign Journal, 7(3), 104–108. https://doi.org/10.14785/lymphosign-2020-0007

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