Antioxidant enzyme activity and lipid peroxidation in rat liver exposed to celecoxib and lansoprazole under epinephrine-induced stress

Abstract

The effect of exposure of celecoxib and lansoprazole on antioxidant enzymes and lipid peroxidation has been studied in liver of rats. We considered the content of malondialdehyde (MDA), and activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). MDA content was significantly decreased for 35% in rats treated with celecoxib and for 72% in combination with lansoprazole. The increase of SOD activity after administration of celecoxib in the liver was 29% and observed decrease of CAT (12%), GPx (5%) and GR (33%) activities. Similarly, an increase in the antioxidant enzymes was found after administration of celecoxib and lansoprazole such as increase of SOD activity (44%) and decrease of CAT (16%), GPx (9%) and GR activities (46%). The current study shows that exposure of celecoxib and lansoprazole increases the endogenous antioxidant defense system and decreases the lipid peroxidation in rat liver tissues under epinephrine-induced stress and confirms the important role of these drugs in the reduction of stress-induced cellular toxicity.