Evaluation of size and zeta potential of DNA/carrier complexes

Abstract

To date, many kinds of non-viral gene vectors, such as cationic liposomes, cationic polymers, e.g., poly-l-lysine, polyethyleneimine (PEI), and cationic dendrimers, have been developed (Niidome and Huang 2002). These non-viral vectors have been a great advance clinically due to their low toxicity, low immunogenicity, and ease of preparation. And while some of them have already been applied to clinical use, the transfection activities are still low and have to be improved.