Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.
CITATION STYLE
Fremeau, R. T., Kam, K., Qureshi, Y., Johnson, J., Copenhagen, D. R., Storm-Mathisen, J., … Edwards, R. H. (2004). Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science, 304(5678), 1815–1819. https://doi.org/10.1126/science.1097468
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