Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration

Abstract

Background: Angiotensin II induces skeletal muscle atrophy, but the function of other renin-angiotensin system components in skeletal muscle physiology is understood poorly. Results: Angiotensin II type 2 receptor (AT2R) blockade inhibits skeletal muscle regeneration and myoblast differentiation. Conclusion: AT2R positively regulates skeletal muscle regeneration. Significance: Stimulation of AT2R signaling may be beneficial in muscle wasting conditions.