Preparation of levodopa-2, 6-dimethyl-β-cyclodextrin inclusion by saturation solution process

Abstract

Levodopa-2,6-Dimethyl-β-Cyclodextrin inclusion was prepared by saturation solution process for nasal administration. The best inclusion technology was screened out with orthogonal design by the alteration of the experimental conditions, such as temperature, stir speed, and ratio of levodopa to 2,6-Dimethyl-β-Cyclodextrin. The yield and content of levodopa inclusion complex prepared by the saturation solution method were 76.76% and 16.83%, respectively; the inclusion condition involved that the mol ratio of levodopa to 2,6-Dimethyl-β-Cyclodextrin was 1:1, stir temperature was 40°C, inclusion time was 4 hours, and stir speed was 300 rpm. This method is simple and easy to operate. Copyright © Informa Healthcare USA, Inc.