Chiral discrimination in the solid state: Applications to resolution and deracemization

Abstract

Chiral discrimination in the solid state is addressed in several ways: (1) thermodynamics of equilibrium, (2) crystal packing, and (3) in a dynamic mode, by entrainment and deracemization. Based on several deviations from a pure even distribution, the hypothesis of clusters of conglomerates is put forward. For a chiral molecule, without any clear filiation from a known conglomerate, the question of prediction of full discrimination in the solid state remains open. Nevertheless, several avenues for new researches in that field are proposed. Progress on detection of conglomerates is detailed. New developments in preferential crystallization coupled or not with racemization in the liquid phase are detailed.