Introduction: Recently, a non-invasive, continuous ventricular stroke volume monitoring system using skin electrodes has been developed. In contrast to impedance-based methods, the new technique (ventricular field recognition) enables measurement of changes in ventricular volume. A prototype using this new method was built (the hemologic cardiac profiler, HCP) and validated against a reference method in a pig model during variations in cardiac output.Methods: In six Dalland pigs, cardiac output was simultaneously measured with the HCP (CO-HCP), and an invasive ultrasonic flow-probe around the ascending aorta (CO-FP). Variations in CO were achieved by change in ventricular loading conditions, cardiac pacing, and dobutamine administration. Data were analysed according to Bland-Altman analysis and Pearson's correlation.Results: Pearson's correlation between the CO-HCP and the CO-FP was r = 0.978. Bland-Altman analysis showed a bias of - 0.114 L/minute, and a variability of the bias (2 standard deviations, 2SD) of 0.55 L/minute.Conclusions: The results of the present study demonstrate that CO-HCP is comparable to CO-FP in an animal model of cardiac output measurements during a wide variation of CO. Therefore, the HCP has the potential to become a clinical applicable cardiac output monitor. © 2011 Konings et al.; licensee BioMed Central Ltd.
CITATION STYLE
Konings, M. K., Grundeman, P. F., Goovaerts, H. G., Roosendaal, M. R., Hoefer, I. E., Doevendans, P. A., … Buhre, W. F. (2011). In-vivo validation of a new non-invasive continuous ventricular stroke volume monitoring system in an animal model. Critical Care, 15(4). https://doi.org/10.1186/cc10306
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