Background: Carbapenem-resistant Acinetobacter baumannii infection is a concern in developing countries due to high incidence, few therapeutic options, and increasing costs. Objective: Characterize and analyze the antibiotic susceptibility patterns of carbapenem-resistant A. baumannii isolates and evaluate clinical data of meningitis and bacteremia caused by this microorganism. Methods: Twenty-six A. baumannii isolates from 23 patients were identified by MALDI-TOF and automated methods and genotyped using pulsed field genotyping electrophoresis. Clinical data and outcomes were evaluated. Susceptibility of isolates to colistin, tigecycline, meropenem, imipenem, and doxycycline was determined. Results: Mortality due to A. baumannii infections was 73.91%; all patients with meningitis and 7/8 patients with ventilator-associated pneumonia died. All isolates were susceptibility to polymyxin (100%; MIC50, MIC90: 1 μg/mL, 1 μg/mL) and colistin (100%; MIC50, MIC90: 2 μg/mL, 2 μg/mL), and 92% were susceptible to tigecycline (MIC50, MIC90: 1 μg/mL, 1 μg/mL) and doxycycline (MIC50, MIC90: 2 μg/mL, 2 μg/mL). blaOXA-23 was identified in 24 isolates. Molecular typing showed 8 different patterns: 13 isolates belonged to pattern A (50%). Conclusion: Carbapenem-resistant A. baumannii infections mortality is high. Alternative antimicrobial therapy (doxycycline) for selected patients with carbapenem-resistant A. baumannii infection should be considered.
CITATION STYLE
Schuertz, K. F., Tuon, F. F., Palmeiro, J. K., Conte, D., Telles, J. P. M., Trevisoli, L. E., & Dalla-Costa, L. M. (2018). Bacteremia and meningitis caused by OXA-23-producing Acinetobacter baumannii – molecular characterization and susceptibility testing for alternative antibiotics. Brazilian Journal of Microbiology, 49, 199–204. https://doi.org/10.1016/j.bjm.2018.04.002
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