The animal model of adenomyosis

Abstract

Spontaneous adenomyosis is known to occur in several animal species and experimental models were developed in laboratory animals through hormonal manipulation. The induction of adenomyosis in laboratory animals is species and strain dependent and is also highly dependent on the exact timing of the intervention. Neonatal administration of tamoxifen and altered prolactin production in the mouse are the models most widely reported in literature but the functional significance of the presence of adenomyosis in the mouse model and the relevance of these models to the human disease remain unclear.