While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac'h and colleagues compared vitamin D levels with bone fragility fractures in their sarcoidosis clinic. They found that a 25-(OH) vitamin D level between 10 and 20 ng/ml was associated with the lowest risk of bone fractures and paradoxically higher levels increased the risk of bone fractures. Using less vitamin D supplementation may simultaneously lower the risk for bone fracture and hypercalcemia in sarcoidosis. © 2014 Baughman and Lower; licensee BioMed Central Ltd.
CITATION STYLE
Baughman, R. P., & Lower, E. E. (2014, May 23). Goldilocks, vitamin D and sarcoidosis. Arthritis Research and Therapy. BioMed Central Ltd. https://doi.org/10.1186/ar4568
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