The deoxyribonuclease 1 (Dnase1) family is a key family of endonucleases that degrades DNA. Loss of Dnase1 family function causes several diseases where the host’s immune system targets the host, such as systemic lupus erythematosus, hypocomplementemic urticarial vasculitis syndrome.
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Engavale, M., McCord, J., Mapp, B., Nzimulinda, N., Bengtson, E., Sutton, R. B., & Keyel, P. A. (2021). Dnase1 Family in Autoimmunity. Encyclopedia, 1(3), 527–541. https://doi.org/10.3390/encyclopedia1030044