Typically, dendritic cells (DCs) induce peripheral tolerance under steady state but immunity during inflammation or infection. In this issue of Immunity, Jiang et al. (2007) identify disruption of E-cadherin interactions as a unique maturation pathway by which DCs are capable of mediating tolerance. © 2007 Elsevier Inc. All rights reserved.
van den Broek, M. (2007, October 26). Dendritic Cells Break Bonds to Tolerize. Immunity. https://doi.org/10.1016/j.immuni.2007.10.004