Platelet microparticles are submicron vesicles that can support thrombin generation on externalized negatively charged phospholipids. Increased numbers of circulating platelet microparticles have been investigated as the basis of hypercoagulability in a variety of prothrombotic conditions. Measurement of platelet microparticles is not standardized and a number of preanalytic considerations can influence accurate analysis. We describe methodology for light scatter-based flow cytometry as well as impedance-based flow cytometry for the enumeration and characterization of platelet microparticles. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Zwicker, J. I., Lacroix, R., Dignat-George, F., Furie, B. C., & Furie, B. (2012). Measurement of platelet microparticles. Methods in Molecular Biology, 788, 127–139. https://doi.org/10.1007/978-1-61779-307-3_10
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