Site-Specific Artificial Ribonucleases: Conjugates of Oligonucleotides with Catalytic Groups

Abstract

Design of site-specific artificial ribonucleases is one of the most challenging tasks in RNA targeting (Morrow 1994; Häner et aL 1998; Oivanen et aL 1998; Sil’nikov and Vlassov 2001). Apart from being useful molecular biology tools (Hüber 1993; Giegé et aL 2000), such compounds may provide new opportunities for design of therapeutics targeting specific messenger RNAs and viral genomic RNAs (Uhlmann and Peymann 1990; Komyiama and Sumaoka 1998; Trawick et aL 1998; Crook et aL 2000).