Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on alzheimer disease induced in mice by aluminium toxicity

Abstract

Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficiency and biological effectin Alzheimer’s model mice. Materials and Methods: Alzheimer’s disease was induced in mice and treated in parallel by Bioglucur. Results: Results obtained show that the Bioglucur improves impart mental concentration and memory and decrease anxiety thus the storage capacity is improved during the Morris test and even neurons improvement in the histological study in treated mice. Conclusion: The mixture preparation of curcumin and 1,3-β-glucans from Vietnamese medicinal mushrooms increase the bioavibility of curcumin and helps recover neurons in mice Alzheimer’s model.