Abstract
Objective: 5' Fluorouracil (5'FU) loaded chitosan nanoparticle (5FCN) was synthesized and tested for its anticancer activity against Hep G2, the liver cancer cell line. Methods: The morphological characteristic of the 5FCN was visualized in Scanning Electron Microscope (SEM). Results: The 5FCN revealed an IC50 value of 49.50 μl/ml. The study revealed that the 5FCN exhibited excellent anticancer activity against Hep G2 cell line which can be further studied for its application in cancer treatment. Conclusion: Further studies would be focused onto report the drug release efficiency under different physiological conditions and evaluate them in animal model.
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Shaima, C., Moorthi, P. V., & Kutty, S. N. (2016). In vitro anticancer activity of 5’ fluorouracil coated chitosan nanoparticle. International Journal of Current Pharmaceutical Review and Research, 8(4), 6–8. https://doi.org/10.22159/ijcpr.2016v8i4.15267
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