Interferon (IFN) lambdas are important specific components of the mucosal innate immune response. The IFN lambda 4 (IFNL4) dinucleotide polymorphism (ΔG/TT) determines the IFN lambdas and related Interferon-stimulated genes activation, in HCV and other chronic infections. Our group first reported that IFN Lambda response was impaired in high-risk Human Papillomavirus (HPV) cervical infections and in precancerous lesions. Accordingly, we sought to evaluate the possible role of the IFNL4 polymorphism in determining HPV infection outcome. The ΔG/TT alleles were not differently distributed in 221 women with high- or low-risk HPV infection, with HPV infection clearance or persistence, and with abnormal cytology.
CITATION STYLE
Cannella, F., Scagnolari, C., Statzu, M., Sciandra, I., Recine, N., d’Ettorre, G., … Pierangeli, A. (2018). Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome. Virus Genes, 54(2), 319–322. https://doi.org/10.1007/s11262-017-1527-y
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