Hypoglycaemic effects of Parkia biglobosa (Jacq) Benth seed extract in glucose-loaded and NIDDM rats

Abstract

The antidiabetic potentials of the methanol extract of Parkia biglobosa seed (Mimosoideae), its chloroform, hexane, and mother liquor fractions were evaluated in glucose-loaded and alloxan-induced diabetic rats. The methanol extract of the seed exhibited a peak percentage decrease of 64% and 44.1% in blood glucose levels of the glucose-loaded and alloxan-induced diabetic rats respectively. The blood glucose lowering effect of the chloroform fraction (65.7%; p<0.05) was significant and more than that exhibited by the reference drug glibenclamide in the alloxan-induced diabetic rats.