Abstract
Two novel methods of dengue virus inactivation using iodonaphthyl azide (INa) and aminomethyl trioxsalen (aMT) were compared with traditional virus inactivation by formaldehyde. The aMT inactivated dengue-2 virus retained its binding to a panel of 5 monoclonal antibodies specific for dengue-2 envelope protein, whereas inactivation by formaldehyde and INa led to 30-50% decrease in binding. all three inactivated viruses elicited high level virus neutralizing antibodies in vaccinated mice. However, only mice vaccinated with aMT inactivated virus mounted T cell responses similar to live, uninactivated virus. © 2013 Landes Bioscience.
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Raviprakash, K., Sun, P., Raviv, Y., Luke, T., Martin, N., & Kochel, T. (2013). Dengue virus photo-inactivated in presence of 1,5-iodonaphthylazide (INA) or AMT, a psoralen compound (4’-aminomethyl-trioxsalen) is highly immunogenic in mice. Human Vaccines and Immunotherapeutics, 9(11), 2336–2341. https://doi.org/10.4161/hv.25602
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