The synthesis of a 6,8-disubstituted 1,7-naphthyridine 1 and its characterization as a potent and selective phosphodiesterase type 4D inhibitor (IC50=1.5nM) are described. The compound inhibited TNFα-release from human peripheral blood mononuclear cells and was orally active in a model of adjuvant-induced arthritis in rats. © 2002 Elsevier Science Ltd. All rights reserved.
CITATION STYLE
Hersperger, R., Dawson, J., & Mueller, T. (2002). Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: A potent and selective phosphodiesterase type 4D inhibitor. Bioorganic and Medicinal Chemistry Letters, 12(2), 233–235. https://doi.org/10.1016/S0960-894X(01)00720-X
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