Dynamics of Changes in the Fatty Acid Composition of the Auditory Cortex of the Brain in Rats after Single Audiogenic Convulsions

Abstract

A small but significant increase in the quantity of lipid peroxidation-resistant saturated and monounsaturated fatty acids was found in the auditory cortex of Krushinskii–Molodkina (KM) rats, which have an inherited predisposition to audiogenic convulsions, as compared with Wistar rats. Assessment of the fatty acid composition of the auditory cortex in KM rats at 1 h and 1, 3, and 14 days after single audiogenic convulsions revealed changes at three days, evidencing significant depletion of the fatty acid pool at this time. At 14 days, the auditory cortex of KM rats showed recovery of most fatty acids. These results may be of value in developing new approaches to eliminating brain damage after convulsive seizures.