The Analgesic Effect of Zingiber cassumunar Roxb. Ethanol Extract on Mice using Writhing Test Method

Abstract

This study aimed to measure the analgesic effect of ethanol extract of Zingiber cassumunar Roxb. rhizome on mice induced by acetic acid. This study was an experimental study with post-test only control design using writhing test method. The sample of the study consisted of 25 mice which were divided into 3 treated groups of Zingiber cassumunar Roxb. extract; P1, P2, and P3, with dosage of 100 mg/kgBW, 200 mg/kgBW, 400 mg/kgBW respectively, a negative control of distilled water (K-), and a positive control of aspirin (K+). The result showed that (P1) and (P2) significantly decreased the number of the writhing in mice compared to (K-) (p<0,05), with percentage of writhing protection of 49,53% and 57,01%, while (P3) group did not show any analgesic activity. Zingiber cassumunar Roxb. extract of 100 mg/kgBW and 200 mg/kgBW showed the insignificant result of pain inhibition compared to the (K+).