Garlic I: More than just bad breath: Fatal Forty DDI: Garlic, ritonavir, CYP3A4, P-glycoprotein

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Abstract

This case discusses a pharmacokinetic interaction between ritonavir and garlic resulting in abdominal distress. Ritonavir is a cytochrome P450 3A4 and/or P-glycoprotein substrate and garlic is a 3A4 and/or P-glycoprotein inhibitor.

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Lew, V., & Lalwani, K. (2015). Garlic I: More than just bad breath: Fatal Forty DDI: Garlic, ritonavir, CYP3A4, P-glycoprotein. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 953–955). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_215

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