Chemical sensitization remains an important environmental and occupational health issue. A wide range of substances have been shown to possess the ability to induce skin sensitization or respiratory sensitization. As a consequence, there is a need to have appropriate methods to identify sensitizing agents. Although a considerable investment has been made in exploring opportunities to develop methods for hazard identification and characterization, there are, as yet, no validated nonanimal methods available. A state of the art of the different in vitro approaches to identify contact and respiratory capacity of chemicals is covered in this chapter.
CITATION STYLE
Van Den Heuvel, R. L., Lambrechts, N., Verstraelen, S., Nelissen, I. C., & Schoeters, G. E. R. (2012). Chemical sensitization and allergotoxicology. EXS, 101, 289–314. https://doi.org/10.1007/978-3-7643-8340-4_10
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