Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from wheat bran in spontaneously hypertensive rats

Abstract

In this paper, we report an antihypertensive effect of wheat bran peptides (WBP) in spontaneously hypertensive rats (SHR). Following a single administration of WBP, systolic blood pressure (SBP) was significantly reduced at 2hours post-administration and the effect lasted for 6 hours at 10 mg WBP/kg and 8 hours at 50 and 200 mg WBP/kg. When SHR received water containing 0.02% and 0.1% WBP (w/v) ad libitum, SBP was significantly reduced at 10 days post-administration at 0.02% WBP and at 5 days at 0.1% WBP. The effect of both treatments was maintained for 25 days. These results indicate that WBP can exert a potent and long-lasting antihypertensive effect in SHR.