Development of a measure to assess patient trust in medical researchers

Abstract

PURPOSE: Many researchers find it difficult to recruit individuals, particularly minorities, for participation in studies. Mistrust of research and researchers may act as a barrier to participation. The purpose of this study was to develop a scale for assessing trust in medical researchers. METHODS: We developed a multi-item scale by means of multiple cognitive pretests with 25 African American adults and a random-digit-dialing telephone survey of 512 adults in South Carolina. Psychometric characteristics of the Trust in Medical Researchers Scale was assessed by factor analysis using both orthogonal and oblique rotations and Cronbach's α. We assessed construct validity as well as a behavioral intention for future participation in a medical research project. RESULTS: The results of the orthogonal and oblique rotations in the exploratory factor analysis were similar and suggested 2 distinct factors in the final 12 items included in the scale. Cronbach's α for the entire scale was 0.84, whereas it was 0.78 for the first factor of Participant Deception and 0.75 for the second factor of Researcher Honesty. White respondents (28.7 ± 5.6) had greater trust than African American respondents (24.1 ± 6.9) (P