Large scale human epidemiological studies indicate that high intakes of linoleic acid protect against the development of cancer. One mechanism may be the generation of 13-HODE from linoleic acid. 13-HODE prevents cell adhesion to endothelial cells and can inhibit cancer metastasis. 13-HODE synthesis is enhanced by cyclic AMP. Gamma-linolenic acid, a desaturated metabolite of linoleic acid, causes substantial stimulation of 13-HODE synthesis. A fall in gamma-linolenic acid synthesis with age may be related to the age-related fall in 13-HODE formation.
CITATION STYLE
Ziboh, V. A. (1997). The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. Advances in Experimental Medicine and Biology, 433, 291–294. https://doi.org/10.1007/978-1-4899-1810-9_61
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