The correlation of long non-coding RNA intersectin 1-2 with disease risk, disease severity, inflammation, and prognosis of acute ischemic stroke

Abstract

Background: This study aimed to evaluate the predictive value of long non-coding RNA intersectin 1-2 (lnc-ITSN1-2) for acute ischemic stroke (AIS) risk, and investigate its correlation with disease severity, inflammation, and recurrence-free survival (RFS) in AIS patients. Methods: Three hundred and twenty AIS patients were recruited, and plasma samples were collected within 24 hours after admission. lnc-ITSN1-2 expression form plasma was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The National Institute of Health Stroke Scale (NIHSS) score was assessed, and RFS was calculated. Meanwhile, 320 controls were enrolled and plasma samples were collected on the enrollment, and lnc-ITSN1-2 expression was detected by RT-qPCR. Results: lnc-ITSN1-2 expression was increased in AIS patients compared to controls (P