Abstract
Methadone is commonly used for treatment of chronic pain and opioid addiction (only by specially licensed facilities). Its unique pharmacokinetic and pharmacodynamic properties (half-life of 24-60 h), high oral bioavailability (40-99 %), absence of active metabolites, and its relatively low cost make it an attractive alternative to other opioids in special circumstances.
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APA
Chow, R. M., & Issa, M. (2017). Methadone. In Pain Medicine: An Essential Review (pp. 157–158). Springer International Publishing. https://doi.org/10.1007/978-3-319-43133-8_38
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