The influence of Iraqi propolis on the cutaneous wounds healing in local breed dogs

Abstract

Propolis "bee glue" is a nature substance, it is collected from combing of bee hive frames. It has several medical remedies such as anti-microbial, anti-spasm, local anesthetic, and wound healing. The cutaneous wounds repair still remain a big challenge because of skin ability to heal as scar. Therefore, this study aimed to evaluate the Iraqi Propolis to regenerate wound healing. To estimate the total leukocyte count (TLC), wound diameter, histopathological examination of the skin and evaluation of cutaneous fibroblast growth factor (FGF2) level. Results revealed that the TLC recorded significant elevating in control group for all periods after induced wound. While the treated group was returned to normal level in (21 and 28 days). The wound diameter was reduced in the treated group compered with the control group. The histopathological changes of treated group rebounded to a semi-natural pattern in analogical periods compared with control group. The FGF2 level suffered from rapid elevating with small period in propolis group more than control group to heal the wound. Also its increase rebounded the healed cutaneous wounds at last periods of the treated group to regeneration. This assay demonstrated propolis is not only enhancement and acceleration of the wound healing in dogs but also prevent contamination, relive pain, avoid scar formation and minimize hemorrhage therefor it is a typical drug for a topical administration of the wound treatment.