Unveiling the function of a novel protein is a challenging task that requires careful experimental design. Yeast cytokinesis is a conserved process that involves modular structural and regulatory proteins. For such proteins, an important step is to identify their domains and structural organization. Here we briefly discuss a collection of methods commonly used for sequence alignment and prediction of protein structure that represent powerful tools for the identification homologous domains and design of structure-function approaches to test experimentally the function of multi-domain proteins such as those implicated in yeast cytokinesis.
CITATION STYLE
Rincon, S. A., & Paoletti, A. (2016). From structure to function: A comprehensive compendium of tools to unveil protein domains and understand their role in cytokinesis. In Methods in Molecular Biology (Vol. 1369, pp. 379–392). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3145-3_24
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