Environmental Factors Responsible for Obesity and Insulin Resistance in Polycystic Ovary Syndrome

Abstract

It has been shown that environmental factors play a role in the development of obesity and insulin resistance in PCOS women. There is a bulk of evidence that endocrine-disrupting chemicals, advanced glycated end products, and vitamin D deficiency contribute to these disorders. The results of in vitro and in vivo studies have demonstrated different mechanisms involved in the development of these conditions. They suggest new ways of treatment. In addition, they point to the importance of avoidance of exposure to deleterious environmental factors.