Blood coagulation measurements using dynamic speckle technique

Abstract

A series of coagulometers have been developed with the aim of making easier the measurement of coagulation times. A phenomenon that emerges as an alternative for the development of these devices is the use of dynamic laser speckles. It is based on the analysis of time variations of a speckle pattern produced by interference of multiple coherent wavelets scattered by the sample. We present the results of applying correlation analysis to dynamic speckle produced by samples of capillary blood clotting without using any reactive. We also propose a numerical model which describes the obtained curves and a method for measuring coagulation time from this analysis.