Background: Inhibitory factors have been implicated in the failure of remyelination in demyelinating diseases. Myelin associated inhibitors act through a common receptor called Nogo receptor (NgR) that plays critical inhibitory roles in CNS plasticity. Here we investigated the effects of abrogating NgR inhibition in a non-immune model of focal demyelination in adult mouse optic chiasm.
CITATION STYLE
Pourabdolhossein, F., Mozafari, S., Morvan-Dubois, G., Mirnajafi-Zadeh, J., Lopez-Juarez, A., Pierre-Simons, J., … Javan, M. (2014). Nogo receptor inhibition enhances Functional recovery following lysolecithin-induced demyelination in mouse optic chiasm. PLoS ONE, 9(9). https://doi.org/10.1371/journal.pone.0106378
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