Crystallin: A tale of two cells

Abstract

Szutkowska et al. demonstrate that-crystallin plays an essential role in the stabilization of the Na /K /2Cl cotransporter mRNA in the medullary thick ascending limb. However, differential effects of experiments using small interfering RNA to knock down-crystallin in proximal tubule and thick ascending limb cells suggest that additional proteins must contribute to the rapid turnover and selective stabilization of the various mRNAs during metabolic acidosis. © 2009 Inernational Society of Nephrology.