Ace polymorphism in colorectal cancer patients of Kashmiri population

Abstract

The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different cancers and has been implicated as the risk factor for the development of various cancers. To investigate the ACE I/D genotype frequency in CRC cases in Kashmiri population and to correlate it with the known clinicopathological characters of CRC cases. Methods: We designed a case control study, where 86 CRC cases were studied for ACE I/D polymorphism against 150 controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of an I/D polymorphism. Results: Among CRC (86) cases we found the frequency of ACE DD genotype to be 41.86 % (36/86), II 13.95% (12/86) and DI 44.2% (38/86). There was no significant association between the ACE I/D genotype with any of the known clinicopathological characters. Conclusion: The ACE I/D polymorphism is not a significant risk factor in the CRC carcinogenesis in our population. © Sameer et al.