Association between serum TSH levels and metabolic components in euthyroid subjects: A nationwide population-based study

16Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Whether a relationship exists between various metabolic factors and thyroidstimulating hormone (TSH) levels in euthyroid persons remains unknown. This study aims to explore the relationship between TSH levels and metabolic factors in euthyroid individuals. Methods: A total of 2,663 subjects were enrolled from a nationwide population-based crosssectional survey of iodine nutrition, thyroid disease and diabetes in China (2014-2017). Euthyroid individuals were divided into four groups according to quartiles of TSH levels: group A (n=305, 0.3-1.3 mIU/L), group B (n=829, 1.3-2.2 mIU/L), group C (n=673, 2.2-3.2 mIU/L) and group D (n=349, 3.2-4.2mIU/L). Anthropometric parameters, biochemical indicators and TSH levels were determined. Results: A total of 2,156 euthyroid subjects with serum TSH levels within the normal range accounted for 86.8% of the sample. The systolic blood pressure (SBP) in group D was significantly higher than that in the other three groups. Group C displayed significantly lower thyroid peroxidase antibody (TPOAb) levels than the other three groups. Group C also had lower anti-thyroglobulin antibody (TgAb) levels than groups A and D, whereas the TgAb levels in group B were only lower than those in group A. Spearman’s or Pearson’s linear regression analysis showed that SBP (r=0.054; P=0.013) was positively correlated with TSH, but cholesterol (TC) (r=-0.043, P=0.047) was negatively correlated with TSH. Multiple stepwise regression analysis revealed that SBP, the urinary iodine concentration (UIC), waist circumference (WC), body mass index (BMI), TC, triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of serum TSH levels. Conclusion: This large population-based study demonstrates a significant interaction between metabolic factors and TSH levels. An adverse weight status, high blood pressure levels, blood lipid metabolism disorder and excessive iodine intake may be early manifestations of thyroid disease in euthyroid subjects.

References Powered by Scopus

Effect of iodine intake on thyroid diseases in China

663Citations
N/AReaders
Get full text

Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions

253Citations
N/AReaders
Get full text

Iodine Status and Prevalence of Thyroid Disorders after Introduction of Mandatory Universal Salt Iodization for 16 Years in China: A Cross-Sectional Study in 10 Cities

241Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Causal association between serum thyrotropin and obesity: A bidirectional, mendelian randomization study

34Citations
N/AReaders
Get full text

Association Between Serum Thyroid-Stimulating Hormone Levels and Salivary Microbiome Shifts

22Citations
N/AReaders
Get full text

Gender-Specific Impact of Metabolic Obesity Phenotypes on the Risk of Hashimoto's Thyroiditis: A Retrospective Data Analysis Using a Health Check-Up Database

11Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ren, R., Ma, Y., Deng, F., Li, T., Wang, H., Wei, J., … Deng, W. (2019). Association between serum TSH levels and metabolic components in euthyroid subjects: A nationwide population-based study. Diabetes, Metabolic Syndrome and Obesity, 12, 1563–1569. https://doi.org/10.2147/DMSO.S202769

Readers over time

‘19‘20‘21‘22‘23‘24‘2502468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

70%

Researcher 3

30%

Readers' Discipline

Tooltip

Medicine and Dentistry 7

58%

Neuroscience 2

17%

Biochemistry, Genetics and Molecular Bi... 2

17%

Materials Science 1

8%

Save time finding and organizing research with Mendeley

Sign up for free
0