Nucleic acids are the very essence of life, containing the genetic potential of all organisms. However, the sheer size of nucleic acids makes them susceptible to a variety of environmental insults. Of these, ultraviolet-induced damage to nucleic acids has received extensive attention due to its role in disease. The primary step in ultraviolet-induced damage is the absorption of light and the subsequent electronic and structural dynamics on the excited-state potential energy surface. In this chapter, we will review the use of Raman and resonance Raman spectroscopy as a means of obtaining excited-state structural dynamics. Specifically, the application of Raman and resonance Raman spectroscopy to determine the excited-state structural dynamics of nucleic acids and their components will be discussed.
CITATION STYLE
Loppnow, G. R., Billinghurst, B. E., & Oladepo, S. A. (2008). Excited-State Structural Dynamics of Nucleic Acids and Their Components. In Challenges and Advances in Computational Chemistry and Physics (Vol. 5, pp. 237–263). Springer. https://doi.org/10.1007/978-1-4020-8184-2_9
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