In vitro pharmacological screening of macrofungi extracts from the Brazilian northeastern region

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Abstract

Although the use of macrofungi in popular medicine is very common, especially in East Asia, the knowledge about their pharmacological properties is poorly investigated. The aim of this work was to evaluate the pharmacological potential of six species of macroscopic fungi: Phellinus rimosus (Berk.) Pilt (Hymenochaetaceae), Pycnoporus sanguineus (L.) Murrill (Poyporaceae), Hymenochaete rheicolor (Mont.) Lév. (Hymenochaetaceae), Hexagonia papyracea Berk. (Polyporaceae), Datronia caperata (Berk.) Ryvarden (Polyporaceae), and Lepiota sp. (Agaricaceae), collected in the state of Bahia, in north-eastern Brazil. Extracts of these species were obtained and tested to determine their cytotoxicity in normal mouse spleen cells. Immunomodulatory, antineoplasic and antiparasitic activities were investigated. Four macrofungi extracts (Phellinus rimosus, Hymenochaete rheicolor, Lepiota sp., and Datronia caperata) inhibited the lymphoproliferative response stimulated by concanavalin A in 6596% of inhibition in mitogen-induced lymphoproliferation assay, three (Hymenochaete rheicolor, Pycnoporus sanguineus, and Lepiota sp.) inhibited 60-70% of production of nitric oxide by J774 activated by IFN-γ and LPS, and two (Phellinus rimosus and Pycnoporus sanguineus) had antimalarial activity against chloroquine-resistant Plasmodium falciparum (over 60%). We did not find inhibition greater than 60% to the growth of both Leishmania amazonensis and Trypanosoma cruzi. To our knowledge, this is the first description of immunomodulatory activity of Hymenochaete rheicolor (HR), Datronia caperata (DC) and Pycnoporus sanguineus (PS). These results indicate that macrofungi species from the Brazilian north-east have pharmacological activity and are thus a potential source of natural products with medicinal interest. © 2009 Informa UK Ltd.

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Silva, F. S., De Sá, M. S., Costa, J. F. O., Pinto, F. P., Lima, M. S., Lucchese, A. M., … Soares, M. B. P. (2009). In vitro pharmacological screening of macrofungi extracts from the Brazilian northeastern region. Pharmaceutical Biology, 47(5), 384–389. https://doi.org/10.1080/13880200902755226

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