Serum α2-macroglobulin levels in diabetes

Abstract

Serum α2-macroglobulin levels have been determined in diabetic patients by quantitative radial immunodiffusion and compared with those observed in age and sex-matched controls. In addition, the results in diabetics have been analyzed with respect to such variables as the age and sex of the patient, the duration of disease, treatment, control, and the occurrence of retinopathy or nephropathy. The α2-macroglobulin levels in diabetic patients were found to be significantly higher than in age and sex-matched controls, thus confirming previous observations. However, these differences were most apparent in the more extreme age groups. Multiple regression analysis also revealed that the only variables contributing significantly to the regression apart from age and sex were control and retinopathy.