Factors involved in cancer metastasis: A better understanding to "seed and soil" hypothesis

111Citations
Citations of this article
280Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Metastasis has intrigued researchers for more than 100 years. Despite the development of technologies and therapeutic strategies, metastasis is still the major cause of cancer-related death until today. The famous "seed and soil" hypothesis is widely cited and accepted, and it still provides significant instructions in cancer research until today. To our knowledge, there are few reviews that comprehensively and correlatively focus on both the seed and soil factors involved in cancer metastasis; moreover, despite the fact that increasingly underlying mechanisms and concepts have been defined recently, previous perspectives are appealing but may be limited. Hence, we reviewed factors involved in cancer metastasis, including both seed and soil factors. By integrating new concepts with the classic hypothesis, we aim to provide a comprehensive understanding of the "seed and soil" hypothesis and to conceptualize the framework for understanding factors involved in cancer metastasis. Based on a dynamic overview of this field, we also discuss potential implications for future research and clinical therapeutic strategies.

Cite

CITATION STYLE

APA

Liu, Q., Zhang, H., Jiang, X., Qian, C., Liu, Z., & Luo, D. (2017). Factors involved in cancer metastasis: A better understanding to “seed and soil” hypothesis. Molecular Cancer, 16(1). https://doi.org/10.1186/s12943-017-0742-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free