Importance of physical-chemical properties for toxicological risk assessment

Abstract

The toxicokinetic as well as the pharmacokinetic behavior of a foreign substance is determined largely by solubility, molecular size, dissociation behavior, and vapor pressure. All of these parameters have a significant effect on the absorption, distribution, and excretion. Moreover, physicochemical properties ultimately have a strong influence on the environmental behavior and on the toxic activity of a foreign substance. Taken all together, the physicochemical properties are important parameters for risk assessment.